Laura H. Goetz, M.D., MPH, F.A.C.S., D.A.B.O.M.

Laura H. Goetz, M.D., MPH, F.A.C.S., D.A.B.O.M.

Research Division
  • Precision Research
Programs
  • Precision Medicine

Biography

Dr. Laura H. Goetz is the Director of the Precision Medicine Research Clinic at HonorHealth Research Institute in Scottsdale, Arizona. A board-certified surgeon, preventive medicine physician, and obesity medicine specialist, she brings over two decades of experience spanning cancer treatment, prevention, genomics, and clinical research.

Dr. Goetz earned her MD from the University of Minnesota and her MPH in Epidemiology and Biostatistics from UC Berkeley. She completed residencies in General Surgery at Northwestern University and Preventive Medicine at UC San Diego, along with fellowship training in Colorectal Surgery at the University of Minnesota. She has held faculty and leadership positions at UCSF, Scripps Clinic, the Translational Genomics Research Institute, City of Hope, and Human Longevity, Inc., where she served as Head of Phenotyping. She currently serves as Medical Deputy for the XPRIZE Healthspan Competition.

Dr. Goetz is a Fellow of the American College of Surgeons, a Diplomat of the American Board of Obesity Medicine, a combat veteran who served in Iraq as a U.S. Army surgeon, and contributor to cancer prevention policy through the California Department of Public Health. Her peer-reviewed publications span precision medicine, cancer genomics, biological aging, N-of-1 trial design, and the microbiome. She is also a Research Professor at the ASU John Shufeldt School of Medicine and Medical Engineering.

Research Interests & Focus

Dr. Laura Goetz’s research program sits at the intersection of precision medicine, cancer prevention, and longevity science, with the overarching goal of shifting medicine from reactive disease treatment to proactive, individualized health optimization. Central to this effort is the development of N-of-1 clinical trial methodologies—single-subject, adaptive study designs that leverage deep molecular phenotyping and longitudinal biomonitoring to identify the earliest drivers of disease in each individual.

A primary focus is precision cancer prevention, where Dr. Goetz integrates germline genetic testing, polygenic risk scoring, functional DNA repair capacity assays, immune aging biomarkers, and multi-cancer early detection technologies to stratify risk and match high-risk individuals with evidence-based chemoprevention and intensified surveillance. This work spans the full spectrum of hereditary cancer predisposition syndromes, with particular emphasis on closing the gap between genetic risk identification and actionable clinical intervention.

Her longevity and healthspan research explores the biological mechanisms driving aging—including immunosenescence, epigenetic drift, and metabolic dysregulation—using advanced biomarkers such as epigenetic clocks, inflammatory aging scores, and multi-omic profiling to quantify biological age and track the impact of personalized interventions over time. 

Across all of these domains, the Precision Medicine Research clinic serves as a translational bridge—bringing cutting-edge genomic, proteomic, and digital health technologies from the research bench into individualized clinical care, and generating the evidence base needed to make precision prevention the standard of care.

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